Abstract
1-(2-Benzylphenoxy)-2-piperidinopropane phosphate (abbreviated as ASA 158/5) which was introduced by the Pharmacia Research Laboratory (Sweden) is a compound with the following chemical structure (1). According to an unofficial and unpublished report from the Laboratory (2), it has the antitussive potency 2 to 4 times as potent as that of codeine phosphate and its antitussive action may be mainly due to the prevention of impulses from the pulmonary stretch receptors. The present purpose of this study is to confirm the site of antitussive action of the drug.
