Abstract
Lysergic acid diethylamide (LSD-25) and morphine have been shown to antagonise certain actions of each other. LSD-25 antagonises morphine induced analgesia in rats (1) and emesis in dogs (2). It also blocks the miotic action of morphine (3). On the other hand, morphine blocks LSD-25 pyrexia in rabbits (4). The present study was undertaken to investigate if morphine could antagonise the central hypotensive action of LSD-25 reported by Ginzel (5).
