EFFECTS OF SOME CENTRALLY ACTING DRUGS ON BLOOD COAGULATION

Abstract

Many drugs acting on the central nervous system, like, tranquillizers, and barbiturates are amongst the agents used in thromboembolic discorders and before, during or after surgery. In these patients an alteration in the coagulability of blood has a considerable significance. Very little is known, however, regarding the effect of most of these drugs on coagulation, except for occasional clinical reports (1, 2) of haemorrhagic or thrombotic complications in course of therapy. A study of the effect of these drugs on coagulation has, therefore, been under-taken and the results obtained with 25 drugs are being reported here. A preliminary report of part of this work has been published (3).