A POTENT COMPETITIVE INHIBITOR OF 5-HYDROXY-TRYPTAMINE: 3-(2'-BENZYLAMINOETHYL)-5-METHOXYINDOL HYDROCHLORIDE

Abstract

During works on anti-5-hydroxytryptamine activity of tryptamine derivatives, 3-(2'-benzylaminoethyl)-5-methoxyindol hydrochloride (S-8) of which a chemical structure is shown in Chart 1 has been found to be a potent competitive inhibitor of 5-hydroxytryptamine (HT) action on the fundus of the isolated rat stomach, the isolated guinea pig uterus and the isolated guinea pig taenia caecum (taenia coli). It has been also found that S-8 depresses a rise of blood pressure of the rat caused by HT.