Abstract
Since the precursive work of Zondek were reported, many of the reports containing the investigations for the gonadotropic hormone are made public. The excretion of hypophyseal gonadotropin in the urine of castrated persons was discovered in postmenopausal and castrated women by Aschheim (1928) and in castrated men by Hamburger (1931). Recently, it is said that the gonadotropic hormone present in castrated urine is of hypophyseal origin, and in pregnancy, is chorionic (1).
The purpose of this work reported here, was to investigate the character of the gonadotropic activity in the urine of castrated women. Then I started to compare it with the gonadotropic substance in the urine of pregnant women, and then I excluded the toxicity in castrated urine, corrected the method of extraction and established an assay method in order to obtain the high efficacy.
