PHARMACOLOGICAL SIGNIFICANCES OF PEPTIDASE AND PROTEINASE IN THE BRAIN

REPORT 4: EFFECT OF BRADYKININ ON THE CENTRAL NERVOUS SYSTEM AND ROLE OF THE ENZYME INACTIVATING BRADYKININ IN MOUSE BRAIN

Abstract

The existence of a bradykinin-like substance in nervous tissue has been reported (1), and the enzymatic inactivation of bradykinin by a neural tissue extract are also confirmed (2, 3).
The purification and properties of the enzyme in rat brain inactivating bradykinin were reported in preceding papers from this laboratory (4, 5).
This communication describes changes of spontaneous motor activity in mouse after intracerebral injection of bradykinin and the role of the enzyme inactivating bradykinin (kininase) in mouse brain.