Abstract
Chlorpromazine has been reported to suppress cardiac arrhythrnias produced experimentally (1, 2) and those observed in clinical practice (3). Two new phenothiazine derivatives, namely piperacetazine (2-acetyl-10-{-3 [-4-(β-hydroxyethyl)-piperidine] propyl}-phenothiazine) and benzosulfonate (1-methyl-2-{-(2-methylsulfinyl-dibenzothiazinyl-10)-ethyl-1 }-piperidine) have been recently synthesized (4, 5). Hence it is of interest to determine if they possess antiarrhythmic activity.
