TIME COURSE OBSERVATION ON PROTOKYLOL DISTRIBUTION IN RATS FOLLOWING PROTOKYLOL ADMINISTRATION

Abstract

Protokylol, a sympathomimetic drug has been utilized in general clinical practice as a bronchodilator in recent years. To date no reports concerning the actual drug metabolism are available. As a result of our present research, it was found that protokylol in a manner similar to catecholamine, changes into a substance with a high fluorescence intensity by trihydroxyindole reaction. Using this method it has become possible to measure minute amounts of protokylol (1-3).
The present paper outlines a time course observation on protokylol distribution in rats following an intravenous injection of protokylol.