Abstract
The present study was undertaken to investigate the cardiac effects of 5 antidepressive tricyclic derivatives namely imipramine, desipramine, amitriptyline, trimeprimine and noxiptiline (Fig. 1). The following parameters were studied:
1) In vivo: Effects on ECG, their anti-arrhythmic and anticoronarospastic activity.
2) In vitro: Effects on the inotropism, chronotropism and coronary flow.
