Abstract
The antiarrhythmic activities of N-propyl ajmaline was evaluated in anesthetized dogs. N-propyl ajmaline was effective on aconitine-induced atrial and ouabain-induced ventricular arrhythmias. Antiarrhythmic activity of N-propyl ajmaline was ten times more potent than that of ajmaline. Rapid infusion of N-propyl ajmaline induced ventricular flutter and fibrillation, but these effects were abolished by pre-treatment with β-adrenergic blocking agent.
