PREVENTIVE AND CURATIVE EFFECTS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON EXPERIMENTAL PERITONEAL INFLAMMATION IN MICE

Abstract

Protein content of the peritoneal fluid of mice with induced inflammation was determined using a biuret reagent. The amount of protein in the peritoneal fluid was maximal at two hr after the i.p. injection of 1.2% acetic acid solution when the content of protein was tenfold that of normal mice. The increase in protein content in the peritoneal fluid corresponded well with the dye content leaked from the vascular bed. The anti-inflammatory drugs tested were curative as well as preventive on the increased vascular permeability.