Abstract
Pharmacological profile of a new sympathomimetic agent, compound 70-352, is reported herein. This compound was found to directly stimulate a-adrenergic receptors in the cat, guinea pig, rabbit and rat. Activity was similar to that of noradrenaline (NA) but it was only 0.032% as potent as NA on isolated rat uterus. Duration of action of the compound was, however, much longer. Compound 70-352 had no effect on the central nervous system and the acute LD50 in mice was 1000.0 mg/kg i.p.
