METABOLIC STUDIES ON METIAZINIC ACID I ABSORPTION, DISTRIBUTION, EXCRETION AND METABOLISM IN RATS AND RABBITS

Abstract

Absorption, distribution, excretion and metabolism after oral administration of ³H-labelled metiazinic acid were studied. The administrered radioactivity was excreted through both the urinary and fecal routes. The maximum levels of concentration in blood and most tissues were shown within 3 hr after dosing. The highest radioactivity was found in the kidney throughout all experiments. Relatively high radioactivity was observed in inflammatory-treated parts in rats. Unchanged compound, metiazinic acid S-oxide and these conjugates were found in urine and feces. Approximately 60% of the unchanged form was observed in plasma after 6 hr.