Abstract
Effect of 5-dimethyldithiocarbamylpicolinic acid (YP-279), a dopamine β-hydroxylase inhibitor, on the secretion of pancreatic juice induced by dopamine was investigated in preparations of the isolated blood-perfused canine pancreas. Either a single injection (300 μg) or an infusion (100 μg/min) of YP-279 intra-arterially (i.a.) caused no change in the outflow of the pancreatic juice, but the secretagogue effect of dopamine (1-10 μg, i.a.) was enhanced by the infusion of YP-279 (100 μg/min, i.a.) for 60 min. The previous conclusion obtained with fusaric acid was confirmed as follows; the dopamine β-hydroxylase activity controls the dopaminergic mechanism of the pancreatic secretion.
