Abstract
Toman, Swinyard and Goodman (1) found that the extensor component of tonic convulsion produced by supramaximal electroshock stimulation disappeared after the administration of several anticonvulsant drugs. According to this fact they presented a new method to evaluate antiepileptic drugs in experimental animals. Using the similar method in rabbits, we confirmed (2) that phenobarbital, diphenylhydantoin, cyclohexenylmethylbarbituric acid and phenylacetylurea in non-depressant doses protect against the tonic extensor seizure of electroshock.
The present study is an attempt to find what part of brain is responsible for the manifestation of the tonic extensor seizure. Solution of this problem may contribute in deciding the site of action of antiepileptics.
