Abstract
The active anaphylactic bronchoconstriction of rats mediated by IgE-like antibody against DNP-Ascaris was inhibited by intravenous and intratracheal treatment with Y-12, 141 in a dose-dependent manner. In both routes, the inhibitory effect of Y-12, 141 on this response was more potent than that of disodium cromoglycate (DSCG). The oral administration of Y-12, 141 also produced a similar inhibition of the response. The passive anaphylactic bronchoconstriction of guinea pigs mediated by IgG-like antibody against egg albumin was also prevented dose-dependently by treatment with Y-12, 141 given intravenously, but not with DSCG. The present results suggest that Y-12, 141 may be effective for the treatment of allergic bronchial asthma.
