A COMPARISON OF ANTIHYPERTENSIVE EFFECTS OF ATENOLOL AND PROPRANOLOL IN THE SPONTANEOUSLY HYPERTENSIVE, DOCA/SALINE HYPERTENISVE AND RENAL HYPERTENSIVE RATS

Abstract

Antihypertensive effects of a long-term oral regimen of atenolol were studied in SHR, DOCA/saline hypertensive and renal hypertensive rats (one kidney, one clip) in comparison with the effects of propranolol. Both the β-blockers prevented the development of hypertension in SH R but did not affect that in DOCA/saline and renal hypertensive rats. Both of the a-blockers produced no acute hypotensive effects on the established DOCA/saline and renal hypertension of the rat, although they produced a decrease in the heart rate.