Enhanced Responsiveness of the Coronary Blood Vessel of the Dog Heart-Lung Preparation to PGI₂ after Chronic Chemical Sympathectomy

Abstract

Chronic chemical denervation of the sympathetic nervous system with 6-OH dopamine resulted in an augmentation of the coronary blood flow (CBF) increase inherent in the canine heart-lung preparation, but not in an augmented accumulation of 6-keto PGF_1α in the circulating blood. In denervated HLP, 6-keto PGF_1α was lower and the vasodilator response to PGI₂ larger at the start of the experiments. It was concluded that exaggerated increase in CBF was due to a potentiation of the vasodilator response to PGI₂.