Abstract
Choline acetylase is in close connection with general metabolism ; this may be characteristic of this enzyme, in contrast to that of cholinesterase.
Nowadays, much attention is focused on the problem of acetyl donor in enzymatic synthesis of ACh. Nachmansohn has long been of opinion that acetate was the unique acetyl donor, while such metabolite, as citrate or glutamate was nothing more than accelerator (1), though recently he has withdrawn this opinion (2). On the other hand, there is valid evidence that citrate is the main acetyl donor (3, 4).
In this paper, the author has examined enzymatic synthesis of ACh in various tissues of animals, paying special attention to the problem of acetyl donor. The enlightenment of the nature of acetyl donor is concerned not only with this enzyme system, but also with the function of these tissues of organs themselves, in which ACh is formed.
