Cephalothin and Penicillin G Polymers as Elicitors of Rat PCA Mediated by Mouse IgE Antibodies

Abstract

PCA-eliciting activities of cephalothin and penicillin G-polymers were examined in rats sensitized with homologous IgE antibodies of mouse origin. Cephalothin-polymers elicited PCA regardless of the source of antibodies and the methods to raise them, the minimal effective dose being 2 to 20 μg/animal. Penicillin G-polymers provoked PCA only when anti-benzylpenicilloyl IgE antibody of C57BL/6J mouse raised early after immunization was used. The minimal effective dose in this case was 5 μg/animal, being comparable to that of cephalothin polymers.