Inhibition of IgE Antibody Formation by n-Pentyl α-L-Sorbopyranoside

Abstract

Effect of n-pentyl glycosides and alkyl α-L-sorbopyranosides on IgE antibody formation in rats and mice were investigated. When n-pentyl α-L-sorbopyranoside was given subcutaneously or orally, the IgE antibody formation in rats and mice was suppressed, while no suppression of hemagglutinin formation was observed. The study on timing of administration indicated that n-pentyl α-L-sorbopyranoside significantly suppressed the secondary IgE antibody response when administered before the secondary immunization.