J-STAGE Home  >  Publications - Top  > Bibliographic Information

The Japanese Journal of Pharmacology
Vol. 40 (1986) No. 2 P 353-355

Language:

http://doi.org/10.1254/jjp.40.353


-cis-Diamminedichloroplatinum II (cisplatin) is a potent anticancer chemotherapeutic agent. The major limitation in its use is nephrotoxicity, caused by an unknown mechanism. Injection of cisplatin into rats caused a decrease in body weight and an increase in blood urea nitrogen (BUN). These effects were modified by giving a radical scavenger, α-tocopherol, before the cisplatin injection. N-N'-diphenyl-p-phenylenediamine, another powerful radical scavenger, also attenuated the increase in BUN induced by cisplatin. These results suggest that the toxic effects of cisplatin may be related to free radical induced damage.

Copyright © The Japanese PharmacologicalSociety

Article Tools

Share this Article