Lack of Cytoprotection by Acetaminophen against Ethanol-, HCl·Ethanol- and HCl·Aspirin-Induced Gastric Mucosal Lesions in Rats

Abstract

Effects of acetaminophen against gastric mucosal lesions induced by three different necrotizing agents were studied. Acetaminophen (30, 100 mg/kg), given p.o. 0.5 hr before absolute ethanol, HCl· ethanol, or HCl· aspirin administration, afforded no cytoprotection against gastric mucosal lesions induced by the above agents in 24 hr fasted rats. However, 16, 16-dimethyl prostaglandin E₂ (3 μg/kg), given p.o. 0.5 hr before these necrotizing agents, completely prevented development of these lesions.