Effects of Pantoyl-GABA on GABAA and GABAB Receptors in the Rat Brain

Masanobu NAKAHIRO; Nobuo NISHI; Isao FUKUCHI; Daisuke MOCHIZUKI; Susumu KATO; Atsushi MIZUSHIMA; Shuji UCHIDA; Hiroshi YOSHIDA

doi:10.1254/jjp.45.292

Effects of Pantoyl-GABA on GABA_A and GABA_B Receptors in the Rat Brain

Masanobu NAKAHIRO, Nobuo NISHI, Isao FUKUCHI, Daisuke MOCHIZUKI, Susumu KATO, Atsushi MIZUSHIMA, Shuji UCHIDA, Hiroshi YOSHIDA

Author information

JOURNAL FREE ACCESS

1987 Volume 45 Issue 2 Pages 292-294

DOI https://doi.org/10.1254/jjp.45.292

Details

Abstract

The interactions of the “antidementia drug” pantoyl-γ-aminobutyric acid (pantoyl-GABA) with γ-aminobutyric acid (GABA) receptors were investigated by studies on bindings of radiolabelled ligands in rat brain. Pantoyl-GABA inhibited the binding of [³H]GABA to GABA_A receptors and those of [³H]baclofen and [³H]GABA to GABA_B receptors in the rat cerebral cortex. These data suggest that pantoyl-GABA interacts with both types of GABA receptors in the rat brain.

Corresponding author

Register with J-STAGE for free!