The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
Effect of Methotrexate on Local Cerebral Blood Flow in Conscious Rats
Shigenori MIZUSAWAYasushi KONDOHMatsutaro MURAKAMIHiroyuki NAKAMICHIHiroshi SASAKIKazuo KOMATSUAkira TAKAHASHIYasutsugu KUDOHKatsuhiro WATANABEYukihiko ONOKazuo UEMURA
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1988 Volume 48 Issue 4 Pages 499-501

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Abstract

The effect of methotrexate (MTX) on local cerebral blood flow (I-CBF) was studied with autoradiographic [14C]-iodoantipyrine methods in normal conscious rats. I-CBF was reduced by 30-57% in the rats given MTX (100 mg or 200 mg/body) as compared to that in the saline injected control group, but no dose-dependent effect was observed. The mechanism of I-CBF reduction by MTX was discussed.

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