Effect of Methotrexate on Local Cerebral Blood Flow in Conscious Rats

Shigenori MIZUSAWA; Yasushi KONDOH; Matsutaro MURAKAMI; Hiroyuki NAKAMICHI; Hiroshi SASAKI; Kazuo KOMATSU; Akira TAKAHASHI; Yasutsugu KUDOH; Katsuhiro WATANABE; Yukihiko ONO; Kazuo UEMURA

doi:10.1254/jjp.48.499

Shigenori MIZUSAWA, Yasushi KONDOH, Matsutaro MURAKAMI, Hiroyuki NAKAMICHI, Hiroshi SASAKI, Kazuo KOMATSU, Akira TAKAHASHI, Yasutsugu KUDOH, Katsuhiro WATANABE, Yukihiko ONO, Kazuo UEMURA

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JOURNAL FREE ACCESS

1988 Volume 48 Issue 4 Pages 499-501

DOI https://doi.org/10.1254/jjp.48.499

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Abstract

The effect of methotrexate (MTX) on local cerebral blood flow (I-CBF) was studied with autoradiographic [¹⁴C]-iodoantipyrine methods in normal conscious rats. I-CBF was reduced by 30-57% in the rats given MTX (100 mg or 200 mg/body) as compared to that in the saline injected control group, but no dose-dependent effect was observed. The mechanism of I-CBF reduction by MTX was discussed.

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