Abstract
Effects of pyrazine derivatives on the day of the first opening of the vagina in juvenile female rats were studied. Tetraethyl and 2, 5-dimethyl pyrazine caused a significant delay in the first vaginal opening day of juvenile female rats, but no delay was noted in the case of 2, 5-diethyl or triethyl pyrazine. These results suggest that tetraethyl and 2, 5-dimethyl pyrazine cause delays in the onset of puberty in juvenile female rats.
