Abstract
Avacan was introduced as an effective synthetic spasmolytic by Brock (1) in 1950. Since then it has been tested by many workers with favorable results. There are a few reports including one by author's colleaque Yamane (2), in our laboratory that the drug, for all its obvious pharmacological actions in vitro, has variable and temporary actions in vivo with a variety of toxicity according to the site of administration.
Experiments were performed in an attempt to clarify the differences in efficacy of the drug in vivo and in vitro.
