The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
Mechanisms of Action of Eperisone on Isolated Dog Saphenous Arteries and Veins
Seiji INOUEKa BIANTomio OKAMURAHideki OKUNISHINoboru TODA
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JOURNALS FREE ACCESS

1989 Volume 50 Issue 3 Pages 271-282

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Abstract

Effects of eperisone, an antispasmodic in skeletal muscle, were investigated in helical strips of dog saphenous artery and vein. Eperisone relaxed saphenous arteries and veins previously contracted with norepinephrine, serotonin, acetylcholine, K+, or Ba2+; but in contrast, it produced contractions in the blood vessels contracted with prostaglandin (PG) F. Treatment with eperisone attenuated the contractions induced by norepinephrine and serotonin in the arteries and those by clonidine and phenylephrine in the veins. Eperisone inhibited angiotensin II-induced relaxations, mediated possibly by endogenous PGI2, but did not alter relaxations caused by exogenous PGI2. Treatment with eperisone (10-5 M) potentiated the contractile response to electrical stimulation of adrenergic nerves; the potentiating effect was suppressed by yohimbine. The eperisone-induced contraction in PGF-contracted arteries was inhibited by treatment with indomethacin or aspirin, although cyclooxygenase activity was not inhibited by eperisone. These results may indicate that eperisone blocks postjunctional α1- and α2-adrenergic, muscarinic, serotonergic receptors and prejunctional α2 adrenoceptors and reduces PGI2 synthesis via a mechanism other than cyclooxygenase inhibition.

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