Injurious Effect of Buthionine Sulfoximine, an Inhibitor of Glutathione Biosynthesis, on the Lethality and Urotoxicity of Cyclophosphamide in Mice

Abstract

The effect of buthionine sulfoximine (BSO), a glutathione biosynthesis inhibitor, on the acute lethal toxicity and urotoxicity induced by cyclophosphamide (CPA) was examined in mice. Pretreatment of mice with BSO (500 mg/ kg, i.p.) 5 hr prior to CPA resulted in enhanced lethality and urotoxicity of CPA. In contrast, administration of cysteamine decreased the lethality and urotoxicity of CPA.