Abstract
We attempted to develop a non immunologically induced asthma model using the calcium ionophore A23187. Inhalation of A23187 (0.001-0.005%) for 5 min in male Hartley guinea pigs caused a marked bronchoconstriction in a dosedependent manner with negligible effect on systemic blood pressure. The A231 87induced bronchoconstriction was strongly inhibited by chlorpheniramine and FPL55712. These results indicate that an asthma-like bronchoconstriction was induced by inhalation of A23187 in guinea pigs, and the main chemical mediators involved in this response would be histamine and peptidoleukotrienes.
