Pharmacological Activity of Angiotensin-II Modified by Tyrosine Sulfation

Abstract

An angiotensin-II analogue with a sulfated tyrosine residue was prepared by arylsulfotransferase treatment of synthetic human angjotensin-II. Its biological activities were studied in isolated smooth muscles, and its effect on blood pressure was determined. The sulfated angiotensin-II (All-S) was about 15-30 fold less potent than angjotensin-II (All) for ileum contraction and gallbladder contraction. The hypertensive potency of AII-S was about 30-fold less than that of All.