Effect of Polyoxyethylene-Modified Superoxide Dismutase on Recovery of Myocardial Dysfunction after Coronary Stenosis in Dogs

Abstract

The effects of superoxide dismutase modified with polyoxyethylene (SOD-POE) on impairment of myocardial segment shortening (SS) during coronary stenosis plus pacing-induced tachycardia (CSPT) and the recovery after reperfusion was examined in anesthetized dogs. SOD-POE or saline was administered i.v. 30 min before reperfusion. Changes in hemodynamic variables and SS by CSPT were similar in both groups. However, the SOD-POE group showed improved recovery of SS compared with the control group. Results indicate that oxygenderived free radicals may partially be involved in the genesis of myocardial dysfunction after CSPT-induced regional ischemia.