The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
Binding Profile of SM-9018, a Novel Antipsychotic Candidate
Terufumi KATOAkira HIROSEYukihiro OHNOHiroshi SHIMIZUHiroyasu TANAKAMitsutaka NAKAMURA
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1990 Volume 54 Issue 4 Pages 478-481

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Abstract

The present study employed various receptor-binding assays to clarify the biochemical characteristics of SM-9018. SM-9018 possessed very high affinity for 5-HT2, D2 and 5-HT1A receptors (K1=0.61, 1.4 and 2.9 nM, respectively), and it had moderate affinity for α1, and D1 receptors (K1=17 and 41 nM, respectively). However, SM-9018 had only negligible affinity for α2, opiate, glutamate, phencyclidine, benzodiazepine and GABAA receptors. These results suggest that SM-9018 may be a novel antipsychotic agent with binding affinity for 5-HT2 and 5-HT1A receptors.

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