The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
ISSN-L : 0021-5198
Forskolin Preferentially Dilates the Afferent Arteriole in the Canine Kidney
Toshiaki TamakiKouichi HasuiTetsuo ShojiYasuharu AkiHideyasu KiyomotoHiroshi IwaoYouichi Abe
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1991 Volume 55 Issue 1 Pages 161-164

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Abstract

Intrarenal infusion of forskolin (0.2, μg/kg/min) in anesthetized dogs increased renal blood flow (RBF) and glomerular filtration rate (GFR) to the same degree but did not change the mean arterial pressure or heart rate. Forskolin also increased urine flow and urinary sodium excretion. The proportional increases in RBF and GFR may result from a preferential action of forskolin to dilate the afferent arteriole.

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