Abstract
Roles of nicotinic receptors in the dorsal motor nucleus of the vagus (DMV) in the regulation of gastric motility were investigated in urethane-anesthetized rats in which an intragastric balloon had been placed. Nicotine (0.1 nmole) microinjected into the DMV but not the nucleus ambiguus induced dual changes, a decrease followed by an increase in gastric motility. Administration of 0.1 nmole of hexamethonium into the DMV significantly inhibited the decrease in gastric motility induced by intravenously administered nicotine.
