Gastric Antisecretory Activity of 15(R)-15-Methylprostaglandin E₂, Arbaprostil, in Dogs

Abstract

The gastric antisecretory activity of 15(R)-15-methylprostaglandin E₂ (arbaprostil) was compared with that of natural prostaglandin (PG) E₂ in Pavlov pouch dogs. Arbaprostil significantly inhibited pentagastrin and food-stimulated gastric secretion when it was administered directly into the pouch at a dose of 10-30 μg/pouch and 30-300 μg/pouch, respectively. Natural PGE₂, however, was inactive up to 1000 μg/pouch. The data indicate that arbaprostil is a potent, long-acting orally active antisecretory drug that may be useful for the treatment of peptic ulcer disease.