Selectivity of Bevantolol Hydrochloride towards α- and β-Adrenoceptor Subtypes in Rat Cerebral Cortex

Abstract

Selectivity of bevantolol hydrochloride (NC-1400) towards α- and β-adrenoceptor subtypes of rat cerebral cortex was examined in binding experiments and compared with propranolol. Bevantolol biphasically displaced the ³H-dihydroal-prenolol binding. The affinity of bevantolol to β₁-adrenoceptor was equal to that of propranolol. Bevantolol displaced ³H-prazosin binding monophasically but not ³H-p-aminoclonidine binding. These results suggest that bevantolol is a β₁-adrenoceptor antagonist with a relatively high affinity to α₁-adrenoceptor subtypes.