Inhibitory Effect of (4R)-Hexahydro-7, 7-Dimethyl-6-Oxo-1, 2, 5-Dithiazocine-4-Carboxylic Acid (SA3443), a Novel Cyclic Disulfide, on the Production of TNF-Like Factor from Propionibacterium Acnes-Primed Rat Liver Macrophages/Kupffer Cells

Abstract

The effect of (4R)-hexahydro-7, 7-dimethyl-6-oxo-1, 2, 5-dithiazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide, on tumor necrosis factor (TNF)-like factor production from Propionibacterium acnes (P. acnes)-primed rat liver macrophages/Kupffer cells was investigated. A remarkable increase in TNF-like activity was detected in the culture supernatants of the liver macrophages/Kupffer cells from P. acnes-treated rats. At concentrations of 1 × 10^-6 to 1 × 10^-4 M, SA3443 significantly inhibited the production/release of TNF-like factor from these P. acnes-primed/activated liver macrophages/Kupffer cells.