The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
ISSN-L : 0021-5198
Effect of KRN2391, a Novel Vasodilator, on Various Experimental Anginal Models in Rats
Katsuhiko HaradaYuzo FukataAtsushi MiwaSoichiro KanetaHideaki FukushimaNobuyuki Ogawa
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1993 Volume 63 Issue 1 Pages 35-39


The antianginal effect of KRN2391, N-cyano-N''-(2-nitroxyethyl)-3-pyridinecarboximid-amide monomethanesulfonate, on various anginal models in rats was compared with those of nifedipine and nicorandil. Angina pectoris was induced by methacholine or isoproterenol, and the change in the ST-segments in the electrocardiogram (ECG) was used as the parameter to indicate angina pectoris. The intracoronary administration of methacholine (3 μg) produced an elevation in the ST-segment of the ECG. This ST-elevation was inhibited by the intravenous administration of KRN2391 (30 and 100 μg/kg), nifedipine (100 and 300 μg/kg) and nicorandil (1000 and 3000 μg/kg). The administration of isoproterenol (10 μg/kg/min, i.v.) produced a depression of the ST-segment of the ECG. The intravenous administration of KRN2391 (100 μg/kg), nifedipine (100 μg/kg) and nicorandil (3000 μg/kg) inhibited the ECG changes induced by isoproterenol. These results suggest that KRN2391 exerts a potent protective effect on angina pectoris models compared with nifedipine and nicorandil. KRN2391 appears to be useful as an antianginal drug.

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