Inhibitory Effect of KW-3635, a New Thromboxane A₂-Receptor Antagonist, on Arterial Thrombosis in Guinea Pigs

Abstract

The antithrombotic effects of the thromboxane (TX) A₂-receptor antagonist and aspirin were determined using a photochemically-induced arterial thrombosis model in the femoral arteries of guinea pigs. KW-3635 (sodium (E)-11-[2-(5, 6-dimethyl-1-benzimidazolyl)ethylidene]-6, 11-dihydrodibenz[b, e]-oxepine-2-carboxylate monohydrate) and BM-13505, both of which are TXA₂-receptor antagonists, and aspirin inhibited the thrombus formation at the doses that inhibited the ex vivo platelet aggregation induced by sodium arachidonate (100 μM) or collagen (3 μg/ml). These results support the notion that TXA₂ is an important mediator in the present model of arterial thrombogenesis.