Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1): Changes in the [3H]QNB Binding

Tetsuo Hayashi; Kiyofumi Yamada; Takaaki Hasegawa; Seiichi Ishihara; Tsutomu Kameyama; Tadaomi Morimasa; Takao Kaneyuki; Toshikiyo Shohmori; Toshitaka Nabeshima

doi:10.1254/jjp.64.303

Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1): Changes in the [³H]QNB Binding

Tetsuo Hayashi, Kiyofumi Yamada, Takaaki Hasegawa, Seiichi Ishihara, Tsutomu Kameyama, Tadaomi Morimasa, Takao Kaneyuki, Toshikiyo Shohmori, Toshitaka Nabeshima

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Keywords: Kamikihito, [³H]QNB binding, [³H]TCP binding

JOURNAL FREE ACCESS

1994 Volume 64 Issue 4 Pages 303-306

DOI https://doi.org/10.1254/jjp.64.303

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Abstract

Using in vitro autoradiography, we investigated the effects of Kamikihito (KKT), a traditional Chinese medicine, on the specific binding of [³H]quinuclidinyl benzilate (QNB) and [³H]N-(1-[2-thienyl]cyclohexyl)-3, 4-piperidine (TCP) in the rat brain. The B_max but not the K_d values for [³H]QNB binding to the caudate/putamen and accumbens in aged rats were lower than those in young rats. The [³H]TCP binding was also decreased in aged rats compared with that in young rats. Long-term administration of KKT modulated the [³H]QNB binding in young but not aged rats.

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