The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
Angiotensin II-Induced Pulmonary Edema in a Rabbit Model
Takatsugu YamamotoLi-man WangKazuro ShimakuraMasaki SanakaYuichi KoikeSatoru Mineshita
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1997 Volume 73 Issue 1 Pages 33-40

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Abstract

We conducted the present study to propose a rabbit model of pulmonary edema (PE)induced by angiotensin II (All)and to test the preventive effect of losartan on this form of PE. All was administered to rabbits intravenously at 50, 100, 150 or 300 μg/kg, either by continuous infusion (10 min)or by bolus injection (30 sec). Continuously administered All (150 μg/kg)induced PE in most cases, while a bolus injection of the same dosage did not. Additionally, the incidence of PE increased with higher dosages of All when it was infused continuously. A newly established parameter, the area under the systolic blood pressure-time curve corrected by baseline (cAUC), was prone to rise as the incidence of PE increased. Moreover, cAUC signficantly correlated with the wet-dry lung weight ratio (r=0.66, P<0.05). Subsequently, 0.5 or 3.0 mg/kg of losartan was given before continuous infusion of 150 μg/kg of All. The higher dosage of losartan prevented PE completely, while the lower one did so moderately. We concluded that intravenous administration of All induces PE, probably as a result of increasing afterload. Furthermore, an adequate dosage of losartan can prevent PE because it reduces the pressor effect of All.

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