Suppression of Ischemic Edema in Mice by Manganese-Hyaluronate Conjugate

Katsukiyo Sakurai; Mariko Andoh; Motoyuki Yamada; Yoh Kodera; Hiroyuki Nishimura; Misao Hiroto; Ayako Matsushima; Masaaki Aoyama; Hisao Yamamoto; Yuji Inada

doi:10.1254/jjp.74.117

Katsukiyo Sakurai, Mariko Andoh, Motoyuki Yamada, Yoh Kodera, Hiroyuki Nishimura, Misao Hiroto, Ayako Matsushima, Masaaki Aoyama, Hisao Yamamoto, Yuji Inada

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Keywords: Manganese-hyaluronate conjugate, Ischemic edema, Reactive oxygen species

JOURNAL FREE ACCESS

1997 Volume 74 Issue 1 Pages 117-120

DOI https://doi.org/10.1254/jjp.74.117

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Abstract

Manganese-hyaluronate conjugate (Mn-HA) was synthesized from a diethylenetriaminepentaacetic acid derivative of hyaluronic acid and manganese ion. The conjugate markedly scavenged superoxide anion in vitro and exhibited much higher anti-inflammatory activity than superoxide dismutase in suppressing paw edema in mice when intravenously injected 30 min before the initiation of ischemia.

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