The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
ISSN-L : 0021-5198
Effects of Oral Administration of Soybean Lecithin Transphosphatidylated Phosphatidylserine on Impaired Learning of Passive Avoidance in Mice
Masayoshi FurushiroSatoru SuzukiYoshiyuki ShishidoMasashi SakaiHideyuki YamatoyaSatoshi KudoShusuke HashimotoTeruo Yokokura
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1997 Volume 75 Issue 4 Pages 447-450

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Abstract

Soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) was investigated for its effect on the impaired learning of a passive avoidance task by mice induced by scopolamine or cycloheximide. SB-tPS (240, 360, 480 mg/kg) administered orally significantly prolonged the step-through latency shortened by scopolamine. SB-tPS (240 mg/kg) administered orally also prolonged the step-through latency shortened by cycloheximide. These results suggest that the effect of SB-tPS on the impaired learning behavior may be related not only to the cholinergic system but also the serotonergic system.

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