Abstract
The application of the intracellular microelectrode, of the type developed by Ling and Gerard (1). to single cells has provided many new ways for investigation and supplied information otherwise unobtainable. This technique also has been applied to studies on the excitability of the heart by numerous workers, and Brooks et al. (2), Weidmann (3), Hecht (4) and Matsuda et al. (5) have presented reviews on these studies.
In our previous paper (6), the effects of veratrine, aconitine, guanidine, quinine etc. on the membrane activities of the toad sartorius muscle with an intracellular recording electrode were reported.
The present experiments have been designed to determine the mode of action of drugs, such as acetylcholine. epinephrine, cardiac glycosides, antiarrhythmic agents, veratrine, chelating agents etc. on the membrane potentials of the rabbit ventricular muscle by means of the intracellular microelectrode.
