STUDIES ON THE CONJUGATION OF GLUCURONIC ACID WITH MORPHINE

PART 2: INFLUENCE OF EXOGENOUS GLUCURONIC ACID UPON THE EXCRETION OF FREE AND BOUND MORPHINE IN URINE OF RABBITS

Abstract

It has been already reported by the author (1) that exogenous glucuronic acid should be utilized for the conjugation with morphine in animal body. In order to prove this fact directly, the author measured the amount of free and bound morphine excreted into the urine of the animal after morphine only or morphine and sodium glucuronate (or glucuronolactone) has been administered.