Clinico-pathological Factors Influencing Renal Crystalline Deposition with Special Reference to Calcium Oxalate

Abstract

One thousand autopsy cases were studied in regard to the clinico-pathological factors influencing renal crystalline deposition. Cases with calcium oxalate crystals (CaOX group) were 67, cases with leucine like crystals (LLC group) were 105, and cases with CaOX+LLC were 28.1. Significant factors found through 3 groups were oliguria, albuminuria, anemia, decrease of Ht, increased erythrocyte sedimentation rate, hypoalbuminemia, increased serum α₂-gl, disturbances of liver function, hypocalcemia, azotemia, decreased PSP excretion, blood transfusions, supplemental fluids of large amounts, vitamins, diuretics, antibiotics, and surgical operations.2. Oliguria, albuminuria, anemia, azotemia, supplemental fluids of large amounts, diuretics, and surgical operations were found in markedly high incidences in all 3 groups. These factors seemed to be the important and common causes to/or results of/the renal tubular degeneration.3. In the CaOX group, disturbances of the renal function such as alubuminuria, abnormalities in urinary sediments, increased serum α₂-gl, azotemia and decreased PSP excretion were marked, and a close relationship between CaOX deposition and renal diseases was supposed. In the LLC group, disturbances of the liver functions such as bilirubinuria, jaundice and increased GOT was significant and influence of liver diseases upon LLC deposition was considered. In the CaOX+LLC group, the findings were roughly intermediate between those in the CaOX and LLC groups. These findings perfectly coincided with pathological findings already reported by the author.4. This is the first report studied on the factors for renal CaOX and LLC depositon respectively.