Abstract
Many studies on pathogenesis of acute renal failure have been previously reported by many investigators. In recent years, some patients of postoperative acute renal failure, which pathogenesis was not clear, have been treated in our clinic. In addition, same cases have been reported in many other institutes. All of them were administrated Kanamycin (IBM) and sodium-alginate before or after operation . I thought that the coindental administration of antibiotics and sodium-alginate effected for renal function and tissus. So, I have experimented on the renal damage in rabbits, which the coincidental administration of antibiotics and sodium-alginate was been done, by light and electron microscopic findings and blood urea nitrogen levels. The results of this experiment were as follows. 1) Acute renal failure was surely produced by the coincidental administration of aminoglycocidal antibiotics (kanamycin (KM), paromomycin (PM), neomycin (NM)), except streptomycin (SM), and sodium-alginte in state of dehydration and postoperation. 2) The grade of renal functional and morphological damage was in order to NM, PM, IBM, and SM. 3) Acute rnal failure was not produced by the coincidental administration of polypeptid antibiotics colimycin (CL) or penicillin and sodium-alginata. 4) Characteristic morphological findings of this acute renal failure were necrosis of proximal convolted tubular cells and in early stage the appearance of PAS positive, high electron dense prectipitate in proximal tubular lumen and the appearance and destruction of lysosome in proximal tubular cells.5) Electron microscopic observations suggested that lysosome played an important role to make the necrosis of proximal tubular cells, and these findings were established 3 hours after the coincidental administration of aminoglycocide antibiotics and sodium-alginate.
