Abstract
Experimental exacerbation was induced by means of nonspecific superimposition of serum sickness in rabbits with nephrotoxic nephritis. Rabbits were injected intravenously with 1.0 to 1.8 ml antirabbit kidney duck sera per kg body weight. Four to eight weeks after the first administration, they were injected intravenously with 200 mg bovine serum albumin per kg body weight. Control rabbits were only treated with the same amount of bovine serum albumin. The exacerbation was induced in most rabbits with nephrotoxic nephritis. The grade of exacerbation was parallel with the initial severity of renal damage. This study has clearified that the exacerbation of the nephritis was caused by the different agent from the initial one, even when given in small amount which could not damage the kidney of normal rabbits.
