A case of survival from acute renal failure after 105 days of anuria and oliguria, Analysis of 63 cases of prolonged oliguric cases in the literature

Abstract

A case of prolonged oliguria for 105 days due to potassium bromate poisoning in 22 years old woman who was salvaged by repeated hemodialyses was reported, 37 hemodialyses were necessary to control her uremia. Renal function tests including PSP test, Fishberg concentration test, CThio, CPAH, osmolar clearance, and others were examined on 6, 12, and 18 months after onset of her illness, which showed decreased renal blood flow and glomerular filtration rate, but increased osmolar clearance per nephron. These data suggest that the damage of her renal function was due to decreased nephron population of her kidney and recovery of renal function was by mean of compensatory hypertrophy of the residual nephrons. Also, analysis of clinical date on 63 survival cases of prolonged oliguria over 20 days which were collected in the literatures were made and pathogenesis and prognosis of renal function of these cases were discussed. 27 out of 63 cases were due to acute tubular necrosis, 19 due to bilateral cortical necrosis, 9 due to acute glomerunephritis and other 8 cases respectively. Analysis of these data suggests that the cases with prolonged oliguria over 60 days have markedly poor prognosis regarding renal function. Complete recovery of renal function can be expected in cases of oliguric period under 60 days.